解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS/HYPOTHESIS:The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical....
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1191-9
更新日期:2009-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:New genetic variants associated with susceptibility to type 2 diabetes mellitus have been discovered in recent genome-wide association (GWA) studies. The aim of the present study was to examine the association between these diabetogenic variants and gestational diabetes mellitus (GDM). METHODS:The stud...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1196-4
更新日期:2009-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1204-8
更新日期:2009-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The offspring of mothers with pre-gestational type 1 diabetes (PGDM) may be at increased risk of glucose intolerance and cardiovascular disease in childhood. The underlying causes of these observations, and whether they persist into adulthood, are unknown. The aim of the present study was to test the hy...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1207-5
更新日期:2009-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:We analysed the factors that determine the outcomes of surgical treatment of osteomyelitis of the foot in diabetic patients given early surgical treatment within 12 h of admission and treated with prioritisation of foot-sparing surgery and avoidance of amputation. METHODS:A consecutive series of 185 di...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1131-8
更新日期:2008-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mitochondrial dysfunction has been postulated to underlie muscular fat accumulation, leading to muscular insulin sensitivity and ultimately type 2 diabetes mellitus. Here we re-interpret previously published data on [(13)C]acetate recovery in breath gas obtained during exercise in type 2 diabetic patien...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1069-x
更新日期:2008-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Elevated plasma levels of NEFA impair insulin action. Given the positive linear correlation between NEFA released by adipocytes and plasma NEFA levels, identification of mechanisms controlling adipocyte lipolysis and NEFA release could provide a guide to new therapies for insulin resistance and type 2 d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1036-6
更新日期:2008-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate the action of the glucose-lowering compound sodium tungstate on glucose transport in muscle myotubes and to unravel the molecular events underlying the effects observed. METHODS:We studied the effects of tungstate on 2-deoxy-D: -glucose uptake, levels and transl...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1003-2
更新日期:2008-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Reduced oxidative capacity of the mitochondria in skeletal muscle has been suggested to contribute to insulin resistance and type 2 diabetes. Moreover, a set of genes influencing oxidative phosphorylation (OXPHOS) is downregulated in diabetic muscle. Here we studied whether genetic, epigenetic and non-g...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1018-8
更新日期:2008-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic retinopathy is the most common complication of diabetes and a leading cause of blindness among working-age adults. Anatomical and functional changes occur in the retina and retinal pigment epithelium (RPE) prior to clinical symptoms of the disease. However, the molecular mechanisms responsible ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0991-2
更新日期:2008-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperglycaemia, a key feature of diabetes, is associated with non-enzymatic glycation of plasma proteins. We have shown previously that the reactive alpha-oxoaldehyde, methylglyoxal, non-enzymatically glycates apolipoprotein (Apo)A-I, the main apolipoprotein of HDL, and prevents it from activating lecit...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0986-z
更新日期:2008-06-01 00:00:00
abstract:AIMS:We compared the effects of continuous subcutaneous insulin infusion (CSII) with those of multiple daily insulin (MDI) injections on glycaemic control, risk of hypoglycaemic episodes, insulin requirements and adverse events in type 1 and type 2 diabetes mellitus. METHODS:The electronic databases MEDLINE, EMBASE an...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-008-0974-3
更新日期:2008-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aims were to compare osteoclastic activity between patients with acute Charcot's osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). METHODS:Peripheral blood m...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0992-1
更新日期:2008-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Insulin-like growth factor-1 is a major childhood growth factor and promotes pancreatic islet cell survival and growth in vitro. We hypothesised that genetic variation in IGF1 might be associated with childhood growth, glucose metabolism and type 1 diabetes risk. We therefore examined the association be...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0970-7
更新日期:2008-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Islet autoantibodies are important in diabetes classification and risk assessment, and as endpoints in observational studies. The Diabetes Autoantibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report results for glut...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0967-2
更新日期:2008-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as 'maturity-onset diabetes of the young'. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-0942-y
更新日期:2008-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Wolfram syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) is caused by mutations in the WFS1 gene. Recently, single nucleotide polymorphisms (SNPs) in WFS1 have been reproducibly associated with type 2 diabetes. We therefore examined the effects of these variants on diabetes i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0891-x
更新日期:2008-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-007-0911-x
更新日期:2008-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the prognostic significance of autoantibodies to IA-2beta (IA2betaA) in a large, well-characterised population of islet cell antibody (ICA)-positive relatives followed for 5 years in the European Nicotinamide Diabetes Intervention Trial. METHODS:Autoantibodies to i...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0912-9
更新日期:2008-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS:We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and r...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0895-6
更新日期:2008-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated the potential effects of the Continuous Glucose Monitoring System (CGMS), as compared with self-monitoring of blood glucose, on glycaemic control in children with type 1 diabetes. METHODS:The following electronic databases were searched throughout June 2007: MEDLINE, EMBASE and The Coch...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-007-0884-9
更新日期:2008-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women. METHODS:This was a prospective study of 62,095 middle-aged parous women in Shanghai, China, who had no prior ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0885-8
更新日期:2008-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Proinsulin C-peptide has been implicated in reducing complications associated with diabetes and also in improving blood flow. We hypothesised that incubation of erythrocytes with C-peptide would improve the ability of these cells to release ATP, a stimulus for nitric oxide production. METHODS:Erythrocy...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0853-3
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether the higher prevalence of insulin resistance and glucose intolerance in urban compared with rural Indian men is related to their higher adiposity (percentage body fat) and the associated inflammatory state. METHODS:We studied 149 rural, 142 urban slum and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0847-1
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0865-z
更新日期:2008-01-01 00:00:00
abstract:AIM/HYPOTHESIS:The distinct metabolic properties of visceral and subcutaneous adipocytes may be due to inherent characteristics of the cells that are resident in each fat depot. To test this hypothesis, human adipocytes were differentiated in vitro from precursor stromal cells obtained from visceral and subcutaneous fa...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0841-7
更新日期:2008-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:Knowledge of the within-subject variability of a parameter is required to properly design and calculate sample sizes for longitudinal studies. We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT. METHODS:Thirty-seven adults (13 with normal glucose to...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章
doi:10.1007/s00125-007-0819-5
更新日期:2007-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Peroxisome proliferator-activated receptor gamma (PPARgamma), encoded by the PPARG gene, regulates insulin sensitivity and adipogenesis, and may bind polyunsaturated fatty acids (PUFA) and thiazolidinediones in a ligand-dependent manner. The PPARG proline for alanine substitution at position 12 (Pro12Al...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-007-0826-6
更新日期:2007-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Pancreatic beta cells have highly developed endoplasmic reticulum (ER) due to their role in insulin secretion. Since ER stress has been associated with beta cell dysfunction, we studied several features of beta cell ER in human type 2 diabetes. METHODS:Pancreatic samples and/or isolated islets from non...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0816-8
更新日期:2007-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus. METHODS:Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two trainin...
journal_title:Diabetologia
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00125-007-0783-0
更新日期:2007-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucagon-like peptide-2 (GLP-2) is a gut hormone regulating intestinal growth and nutrient absorption. Recently, GLP-2 has been reported to stimulate glucagon secretion in healthy humans. We sought to clarify the mechanism and physiological significance of this endocrine effect. MATERIALS AND METHODS:T...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0761-6
更新日期:2007-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:To investigate the pathways by which cyclic AMP (cAMP) stimulates glucagon-like peptide-1 (GLP-1) secretion, using the GLUTag enteroendocrine cell line. MATERIALS AND METHODS:GLP-1 release from GLUTag cells was measured in response to agents that increase cAMP, and single cells were studied by fluoresc...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0750-9
更新日期:2007-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glomerular matrix accumulation is a hallmark of diabetic nephropathy. Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix modulation. Here, we studied its role in high glucose-induced collagen elaboration by mesangial cells. METHODS:Primary rat mesangial cells were trea...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0721-1
更新日期:2007-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:High levels of cardiorespiratory fitness (CRF) and physical activity (PA) are associated with a favourable metabolic risk profile. However, there has been no thorough exploration of the independent contributions of cardiorespiratory fitness and subcomponents of activity (total PA, time spent sedentary, ...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-007-0762-5
更新日期:2007-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the gen...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0700-6
更新日期:2007-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:To determine the effects of marine-derived n-3 polyunsaturated fatty acids (PUFA) on established and emerging lipid and lipoprotein cardiovascular risk markers in patients with type 2 diabetes. MATERIALS AND METHODS:We performed a systematic review and meta-analysis of randomised controlled trials comp...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00125-007-0695-z
更新日期:2007-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hypertension, obesity, impaired glucose tolerance and dyslipidaemia are metabolic abnormalities that often cluster together more often than expected by chance alone. Since these metabolic variables are highly heritable and are at least partially genetically determined, the clustering of defects in these...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0720-2
更新日期:2007-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Our aim was to examine the association between markers of insulin resistance and: (1) body fat and waist circumference, taking into account cardiorespiratory fitness in school-aged children; and (2) cardiorespiratory fitness at differing levels of body fat and waist circumference. SUBJECTS AND METHODS:...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0678-0
更新日期:2007-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:In previous studies we have shown a significant involvement of the growth hormone (GH)-IGF axis in animal models of type 1 diabetes mellitus, but the role of this endocrine system in type 2 diabetes mellitus is less well characterised. We therefore examined the endocrine and renal GH-IGF axis changes in...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0663-7
更新日期:2007-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-007-0654-8
更新日期:2007-06-01 00:00:00